Iron, oxygen, and the pulmonary circulation
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چکیده
منابع مشابه
Iron, oxygen, and the pulmonary circulation
The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar oxygen tension, a phenomenon termed hypoxic pulmonary vasoconstriction (HPV). This review describes the time course of this behavior, which occurs in distinct phases, and then explores the importance for HPV of the hypoxia-inducible factor (HIF) pathway. Next, the HIF-hydroxylase enzymes that act as molecular ...
متن کاملOxygen Sensing in the Pulmonary Circulation
Since the original description of hypoxic pulmonary vasoconstriction (HPV) by Von Euler and Liljestrand in 1946, where they concluded, “breathing of pure oxygen lowered the pulmonary arterial pressure and oxygen-lack raised it,” the precise oxygen-sensing mechanism within the lungs has remained an enigma. Nevertheless, there seems to be some agreement to an overall mechanism for HPV: the primar...
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Waypa, Gregory B., and Paul T. Schumacker. Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing. J Appl Physiol 98: 404–414, 2005; doi:10.1152/japplphysiol.00722.2004.—Recently, the mitochondria have become the focus of attention as the site of O2 sensing underlying hypoxic pulmonary vasoconstriction (HPV). However, two disparate models have emerged to explain how mitochondria rea...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2015
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00179.2015